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JHDM2b Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q7LBC6 |
| Other Accession | Q6ZPY7, NP_057688.2 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 191581 Da |
| Antigen Region | 1328-1358 aa |
| Gene ID | 51780 |
|---|---|
| Other Names | Lysine-specific demethylase 3B, 11411-, JmjC domain-containing histone demethylation protein 2B, Jumonji domain-containing protein 1B, Nuclear protein 5qNCA, KDM3B, C5orf7, JHDM2B, JMJD1B, KIAA1082 |
| Target/Specificity | This JHDM2b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1328-1358 amino acids from the C-terminal region of human JHDM2b. |
| Dilution | WB~~1:1000 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | JHDM2b Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KDM3B |
|---|---|
| Synonyms | C5orf7, JHDM2B, JMJD1B, KIAA1082 |
| Function | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. |
| Cellular Location | Nucleus. |
| Tissue Location | Ubiquitous. Highly expressed in placenta, skeletal muscle, kidney, heart and liver. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.
References
Guo, G., et al. Dev. Cell 18(4):675-685(2010)
Allis, C.D., et al. Cell 131(4):633-636(2007)
Blackshaw, S., et al. PLoS Biol. 2 (9), E247 (2004) :
Okazaki, N., et al. DNA Res. 10(4):167-180(2003)
Stryke, D., et al. Nucleic Acids Res. 31(1):278-281(2003)
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