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CCDC61 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q9Y6R9 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 57368 Da |
| Antigen Region | 36-65 aa |
| Gene ID | 729440 |
|---|---|
| Other Names | Coiled-coil domain-containing protein 61, CCDC61 |
| Target/Specificity | This CCDC61 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-65 amino acids from the N-terminal region of human CCDC61. |
| Dilution | WB~~1:1000 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CCDC61 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CCDC61 (HGNC:33629) |
|---|---|
| Function | Microtubule-binding centrosomal protein required for centriole cohesion, independently of the centrosome-associated protein/CEP250 and rootletin/CROCC linker (PubMed:31789463). In interphase, required for anchoring microtubule at the mother centriole subdistal appendages and for centrosome positioning (PubMed:31789463). During mitosis, may be involved in spindle assembly and chromatin alignment by regulating the organization of spindle microtubules into a symmetrical structure (PubMed:30354798). Has been proposed to play a role in CEP170 recruitment to centrosomes (PubMed:30354798). However, this function could not be confirmed (PubMed:31789463). Plays a non- essential role in ciliogenesis (PubMed:31789463, PubMed:32375023). |
| Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, cilium basal body Note=Localization at the centriolar satellite is dependent on intact microtubule network (PubMed:30354798). Localizes at the centriole subdistal appendages and proximal ends (PubMed:31789463). Localized to centrosomal/satellite-like structures with the onset of centrosome separation in early G2 (PubMed:30354798). |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
The specific function of the protein remains unknown.
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$ 150.00
$ 385.00
Cat# AP11587a
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