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LSM7 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UK45 |
| Other Accession | Q9CQQ8, NP_057283.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 11602 Da |
| Antigen Region | 45-72 aa |
| Gene ID | 51690 |
|---|---|
| Other Names | U6 snRNA-associated Sm-like protein LSm7, LSM7 |
| Target/Specificity | This LSM7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-72 amino acids from the C-terminal region of human LSM7. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LSM7 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LSM7 |
|---|---|
| Function | Plays a role in pre-mRNA splicing as component of the U4/U6- U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). |
| Cellular Location | Nucleus |
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Provided below are standard protocols that you may find useful for product applications.
Background
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.
References
Lehner, B., et al. Genome Res. 14(7):1315-1323(2004)
Grimwood, J., et al. Nature 428(6982):529-535(2004)
Lehner, B., et al. Genomics 83(1):153-167(2004)
Ingelfinger, D., et al. RNA 8(12):1489-1501(2002)
Conte, N., et al. Oncogene 21(36):5619-5630(2002)
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