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TBB1 Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - TBB1 Antibody (N-term) AP11781a
    TBB1 Antibody (N-term) (Cat. #AP11781a) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the TBB1 antibody detected the TBB1 protein (arrow).
    detail
  • IHC-P - TBB1 Antibody (N-term) AP11781a
    TBB1 Antibody (N-term) (Cat. #AP11781a)immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TBB1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, WB, E
Primary Accession Q9H4B7
Other Accession NP_110400.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 50327 Da
Antigen Region 4-31 aa
Additional Information
Gene ID 81027
Other Names Tubulin beta-1 chain, TUBB1
Target/Specificity This TBB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-31 amino acids from the N-terminal region of human TBB1.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTBB1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TUBB1
Function Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Cellular Location Cytoplasm, cytoskeleton
Tissue Location Hematopoietic cell-specific. Major isotype in leukocytes, where it represents 50% of all beta-tubulins
Research Areas
Citations (0)
citation

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Background

This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y.

References

Anton, A.I., et al. Ann. Hematol. 89(11):1147-1154(2010)
Yin, S., et al. Mol. Cancer Ther. 9(2):327-335(2010)
Xu, W., et al. Mol. Cancer Ther. 8(12):3318-3330(2009)
Joe, P.A., et al. J. Biol. Chem. 284(7):4283-4291(2009)
Navarro-Nunez, L., et al. Thromb. Haemost. 100(6):1211-1213(2008)

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$ 365.00
$ 140.00
Cat# AP11781a
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