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GAS1 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| FC, IF, IHC-P, WB, E |
|---|---|
| Primary Accession | P54826 |
| Other Accession | Q01721, NP_002039 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 35693 Da |
| Antigen Region | 95-127 aa |
| Gene ID | 2619 |
|---|---|
| Other Names | Growth arrest-specific protein 1, GAS-1, GAS1 |
| Target/Specificity | This GAS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-127 amino acids from the N-terminal region of human GAS1. |
| Dilution | IF~~1:10~50 WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GAS1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GAS1 |
|---|---|
| Function | Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells. Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity). |
| Cellular Location | Cell membrane; Lipid-anchor, GPI- anchor |
Provided below are standard protocols that you may find useful for product applications.
Background
Growth arrest-specific 1 plays a role in growth suppression. GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells. Gas1 is a putative tumor suppressor gene.
References
Ribeiro, L.A., et al. Am. J. Med. Genet. A 152A (7), 1688-1694 (2010) : Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) : Rittie, L., et al. Aging Cell 8(6):738-751(2009) Zhao, L., et al. J. Biol. Chem. 284(39):26273-26285(2009) Dominguez-Monzon, G., et al. Int. J. Dev. Neurosci. 27(4):305-313(2009)
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