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SH2D4A Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q9H788 |
| Other Accession | NP_071354.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 52727 Da |
| Antigen Region | 38-67 aa |
| Gene ID | 63898 |
|---|---|
| Other Names | SH2 domain-containing protein 4A, Protein SH(2)A, Protein phosphatase 1 regulatory subunit 38, SH2D4A, PPP1R38, SH2A |
| Target/Specificity | This SH2D4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-67 amino acids from the N-terminal region of human SH2D4A. |
| Dilution | IHC-P~~1:10~50 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SH2D4A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SH2D4A |
|---|---|
| Synonyms | PPP1R38, SH2A |
| Function | Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T- cell development and function. |
| Cellular Location | Cytoplasm. Note=Located at podocyte foot processes. |
| Tissue Location | Ubiquitously expressed. Aberrantly expressed in some cancers. |
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Provided below are standard protocols that you may find useful for product applications.
Background
SH2D4A inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Li, T., et al. BMB Rep 42(8):516-522(2009)
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
Lapinski, P.E., et al. J. Immunol. 181(3):2019-2027(2008)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
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