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RAD26 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q5T890 |
| Other Accession | NP_001010895.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 176051 Da |
| Antigen Region | 226-254 aa |
| Gene ID | 375748 |
|---|---|
| Other Names | DNA excision repair protein ERCC-6-like 2, 364-, DNA repair and recombination protein RAD26-like, ERCC6L2, C9orf102, RAD26L |
| Target/Specificity | This RAD26 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 226-254 amino acids from the Central region of human RAD26. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RAD26 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ERCC6L2 (HGNC:26922) |
|---|---|
| Synonyms | C9orf102, RAD26L |
| Function | Promotes double-strand break (DSB) end-joining and facilitates programmed recombination by controlling how DNA ends are joined in a spatially oriented manner during repair (By similarity). Also plays a role in DNA repair by restricting DNA end resection in double strand break (DSB) repair (PubMed:24507776, PubMed:37014751). Facilitates replication of complex DNA regions and regulates the maintenance of chromatin structure (PubMed:37014751). |
| Cellular Location | Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Mitochondrion. Chromosome, centromere. Note=Colocalizes with NEK6 in the centrosome (PubMed:20873783). In response to DNA damage, translocates from the cytosol to mitochondria and nucleus in a reactive oxygen species (ROS)-dependent manner (PubMed:24507776). Centromeric localization is facilitated by its interaction with PCNA (PubMed:37014751). |
| Tissue Location | Expressed in bone marrow (at protein level). |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Venter, J.C., et al. Science 291(5507):1304-1351(2001)
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$ 150.00
$ 385.00
Cat# AP12097c
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