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RAD26L/C9orf102 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | Q5T890 |
| Reactivity | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 177 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human RAD26L/C9orf102 |
| Epitope Specificity | 461-560/1561 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Nucleus. |
| SIMILARITY | Belongs to the SNF2/RAD54 helicase family. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a member of the Snf2 family of helicase-like proteins. The encoded protein may play a role in DNA repair and mitochondrial function. Mutations in this gene have been associated with bone marrow failure syndrome 2. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Apr 2014] |
| Gene ID | 375748 |
|---|---|
| Other Names | DNA excision repair protein ERCC-6-like 2, 3.6.4.-, DNA repair and recombination protein RAD26-like, ERCC6L2, C9orf102, RAD26L |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | ERCC6L2 (HGNC:26922) |
|---|---|
| Synonyms | C9orf102, RAD26L |
| Function | Promotes double-strand break (DSB) end-joining and facilitates programmed recombination by controlling how DNA ends are joined in a spatially oriented manner during repair (By similarity). Also plays a role in DNA repair by restricting DNA end resection in double strand break (DSB) repair (PubMed:24507776, PubMed:37014751). Facilitates replication of complex DNA regions and regulates the maintenance of chromatin structure (PubMed:37014751). |
| Cellular Location | Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Mitochondrion. Chromosome, centromere. Note=Colocalizes with NEK6 in the centrosome (PubMed:20873783). In response to DNA damage, translocates from the cytosol to mitochondria and nucleus in a reactive oxygen species (ROS)-dependent manner (PubMed:24507776). Centromeric localization is facilitated by its interaction with PCNA (PubMed:37014751). |
| Tissue Location | Expressed in bone marrow (at protein level). |
Citations (0)
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Application Protocols
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$ 385.00
Cat# AP57639
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