|Application ||WB, E|
|Other Accession||Q63250, Q9QY14, NP_036318.1|
|Calculated MW||33234 Da|
|Antigen Region||87-114 aa|
|Other Names||Forkhead box protein E3, Forkhead-related protein FKHL12, Forkhead-related transcription factor 8, FREAC-8, FOXE3, FKHL12, FREAC8|
|Target/Specificity||This FOXE3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 87-114 amino acids from the Central region of human FOXE3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FOXE3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle (PubMed:22527307, PubMed:25504734). During lens development, controls the ratio of the lens fiber cells to the cells of the anterior lens epithelium by regulating the rate of proliferation and differentiation (By similarity). Controls lens vesicle closure and subsequent separation of the lens vesicle from ectoderm (By similarity). Controls the expression of DNAJB1 in a pathway that is crucial for the development of the anterior segment of the eye (PubMed:27218149).|
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Provided below are standard protocols that you may find useful for product applications.
This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. The protein encoded functions as a lens-specific transcription factor and plays an important role in vertebrate lens formation. Mutations in this gene are associated with anterior segment mesenchymal dysgenesis and congenital primary aphakia.
Reis, L.M., et al. Am. J. Med. Genet. A 152A (3), 582-590 (2010) :
Bremond-Gignac, D., et al. Mol. Vis. 16, 1705-1711 (2010) :
Ali, M., et al. Mol. Vis. 16, 1162-1168 (2010) :
Anjum, I., et al. Mol. Vis. 16, 549-555 (2010) :
Iseri, S.U., et al. Hum. Mutat. 30(10):1378-1386(2009)
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