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Dok5 Antibody (PTB domain)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9P104 |
| Other Accession | NP_060901.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 35464 Da |
| Gene ID | 55816 |
|---|---|
| Other Names | Docking protein 5, Downstream of tyrosine kinase 5, Insulin receptor substrate 6, IRS-6, IRS6, DOK5, C20orf180 |
| Target/Specificity | This Dok5 antibody is generated from rabbits immunized with a recombinant protein (GST-tag removed) from human Dok5. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Dok5 Antibody (PTB domain) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DOK5 |
|---|---|
| Synonyms | C20orf180 |
| Function | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation. |
| Tissue Location | Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T- lymphocytes. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.
References
Liu, X., et al. J Am Acad Child Adolesc Psychiatry 49(1):33-41(2010)
Tabassum, R., et al. BMC Med. Genet. 11, 35 (2010) :
Shi, L., et al. Cell. Signal. 18(11):1995-2003(2006)
Cai, D., et al. J. Biol. Chem. 278(28):25323-25330(2003)
Favre, C., et al. Genes Immun. 4(1):40-45(2003)
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