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SENP7 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BQF6 |
| Other Accession | A7MBJ2 |
| Reactivity | Human, Mouse |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 119658 Da |
| Antigen Region | 709-740 aa |
| Gene ID | 57337 |
|---|---|
| Other Names | Sentrin-specific protease 7, SUMO-1-specific protease 2, Sentrin/SUMO-specific protease SENP7, SENP7, KIAA1707, SSP2, SUSP2 |
| Target/Specificity | This SENP7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 709-740 amino acids from the C-terminal region of human SENP7. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SENP7 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SENP7 {ECO:0000303|Ref.2, ECO:0000312|HGNC:HGNC:30402} |
|---|---|
| Function | Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS. Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (By similarity). Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1 (PubMed:18799455). Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains (PubMed:18799455). Has very low efficiency in processing full-length SUMO proteins to their mature forms (PubMed:18799455). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q8BUH8}. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
SENP7 is a protease that may be involved in two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature conjugatable forms and/or deconjugation of SUMO1, SUMO2 and SUMO3 from targeted substrate proteins.
References
Wiemann, S., et al., Genome Res. 11(3):422-435 (2001).
Nagase, T., et al., DNA Res. 7(6):347-355 (2000).
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