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> home > Products > Primary Antibodies > Antibody Collections > Catalog Updated > OSTC Antibody (C-term)
OSTC Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NRP0 |
| Other Accession | B0K025, Q78XF5, Q7ZWJ3, Q5ZJR3, Q2KID7, Q5M9B7, NP_067050.1 |
| Reactivity | Mouse |
| Predicted | Xenopus, Bovine, Chicken, Zebrafish, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 16829 Da |
| Antigen Region | 90-117 aa |
| Gene ID | 58505 |
|---|---|
| Other Names | Oligosaccharyltransferase complex subunit OSTC, Hydrophobic protein HSF-28, OSTC |
| Target/Specificity | This OSTC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-117 amino acids from the C-terminal region of human OSTC. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | OSTC Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | OSTC (HGNC:24448) |
|---|---|
| Function | Subunit of STT3A-containing oligosaccharyl transferase (OST- A) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:28860277, PubMed:31831667, PubMed:39509507). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER) (PubMed:28860277, PubMed:31831667, PubMed:39509507). Within the OST-A complex, acts as an adapter that anchors the OST-A complex to the Sec61 complex (PubMed:28860277). May be involved in N-glycosylation of APP (amyloid-beta precursor protein) (PubMed:21768116). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1 (PubMed:21768116). |
| Cellular Location | Endoplasmic reticulum. Membrane; Multi-pass membrane protein |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010)
Shibatani, T., et al. Biochemistry 44(16):5982-5992(2005)
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$ 385.00
$ 150.00
Cat# AP12431b
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