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MAN2A2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, IHC-P, E |
|---|---|
| Primary Accession | P49641 |
| Other Accession | NP_006113.2 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 130539 Da |
| Antigen Region | 767-796 aa |
| Gene ID | 4122 |
|---|---|
| Other Names | Alpha-mannosidase 2x, Alpha-mannosidase IIx, Man IIx, Mannosidase alpha class 2A member 2, Mannosyl-oligosaccharide 1, 3-1, 6-alpha-mannosidase, MAN2A2, MANA2X |
| Target/Specificity | This MAN2A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 767-796 amino acids from the Central region of human MAN2A2. |
| Dilution | WB~~1:1000 FC~~1:10~50 IHC-P~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MAN2A2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MAN2A2 |
|---|---|
| Synonyms | MANA2X |
| Function | Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N- glycans; the final hydrolytic step in the N-glycan maturation pathway. |
| Cellular Location | Golgi apparatus membrane; Single- pass type II membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
MAN2A2 catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.
References
Lesch, K.P., et al. J Neural Transm 115(11):1573-1585(2008)
Stelzl, U., et al. Cell 122(6):957-968(2005)
Hillman, R.T., et al. Genome Biol. 5 (2), R8 (2004) :
Misago, M., et al. Proc. Natl. Acad. Sci. U.S.A. 92(25):11766-11770(1995)
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