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SH3D20 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q6ZUM4 |
| Other Accession | NP_001152802.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 98396 Da |
| Antigen Region | 198-226 aa |
| Gene ID | 201176 |
|---|---|
| Other Names | Rho GTPase-activating protein 27, CIN85-associated multi-domain-containing Rho GTPase-activating protein 1, Rho-type GTPase-activating protein 27, SH3 domain-containing protein 20, ARHGAP27, CAMGAP1, SH3D20 |
| Target/Specificity | This SH3D20 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-226 amino acids from the Central region of human SH3D20. |
| Dilution | WB~~1:2000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SH3D20 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ARHGAP27 (HGNC:31813) |
|---|---|
| Function | Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). |
| Cellular Location | Cytoplasm. Membrane; Peripheral membrane protein |
| Tissue Location | Expressed in germinal center B-cell, spleen, chronic lymphocytic leukemia, pancreatic cancer and lung cancer |
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Provided below are standard protocols that you may find useful for product applications.
Background
SH3D20 is a rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity).
References
Edwards, T.L., et al. Ann. Hum. Genet. 74(2):97-109(2010)
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