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ABI2 Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ABI2 Antibody (N-term) AP12566A
    ABI2 Antibody (N-term) (Cat. #AP12566a) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the ABI2 antibody detected the ABI2 protein (arrow).
    detail
  • WB - ABI2 Antibody (N-term) AP12566A
    ABI2 Antibody (N-term) (Cat. #AP12566) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the ABI2 antibody detected the ABI2 protein (arrow).
    detail
  • FC - ABI2 Antibody (N-term) AP12566A
    ABI2 Antibody (N-term) (Cat. #AP12566a) flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC, WB, E
Primary Accession Q9NYB9
Other Accession P62484, NP_005750.4
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 55663 Da
Antigen Region 1-30 aa
Additional Information
Gene ID 10152
Other Names Abl interactor 2, Abelson interactor 2, Abi-2, Abl-binding protein 3, AblBP3, Arg-binding protein 1, ArgBP1, ABI2, ARGBPIA
Target/Specificity This ABI2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human ABI2.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsABI2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ABI2 {ECO:0000303|PubMed:28397838, ECO:0000312|HGNC:HGNC:24011}
Function Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:7590236, PubMed:8649853, PubMed:10498863). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692).
Cellular Location Cytoplasm. Nucleus
Tissue Location Widely expressed. Abundant in testes, ovary, thymus, and colon, with lower but detectable levels in prostate, peripheral blood leukocytes, and spleen.
Research Areas
Citations (0)
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Background

ABI2 may act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May be involved in cytoskeletal reorganization. Regulates ABL1/c-Abl-mediated phosphorylation of MENA.

References

Ryu, J.R., et al. Mol. Cell. Biol. 29(7):1735-1748(2009)
Kano, S., et al. Cancer Res. 68(14):5572-5580(2008)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Li, Y., et al. J. Cell. Sci. 120 (PT 8), 1436-1446 (2007) :
O'Donnell, C.J., et al. BMC Med. Genet. 8 SUPPL 1, S4 (2007) :

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$ 182.50
$ 70.00
Cat# AP12566A
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