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STX8 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UNK0 |
| Other Accession | NP_004844.1 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 26907 Da |
| Antigen Region | 8-36 aa |
| Gene ID | 9482 |
|---|---|
| Other Names | Syntaxin-8, STX8 |
| Target/Specificity | This STX8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-36 amino acids from the N-terminal region of human STX8. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | STX8 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | STX8 |
|---|---|
| Function | Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis- Golgi membranes to the ER. |
| Cellular Location | Membrane; Single-pass type IV membrane protein. Note=Preferentially associated with the early endosome. To a lesser extent, also present in late endosome, the plasma membrane and coated pits (By similarity). |
| Tissue Location | Highly expressed in heart. Also found in brain, kidney, liver, lung, placenta, skeletal muscle, spleen and pancreas |
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Provided below are standard protocols that you may find useful for product applications.
Background
The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to late endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12. Alternative splicing results in multiple transcript variants.
References
Sebastiani, P., et al. Science (2010) In press :
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Henckaerts, L., et al. Clin. Gastroenterol. Hepatol. 7(9):972-980(2009)
Weersma, R.K., et al. Am. J. Gastroenterol. 104(3):630-638(2009)
He, Y., et al. J. Lipid Res. 50(3):398-404(2009)
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