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TM4SF1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P30408 |
| Other Accession | NP_055035.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 21632 Da |
| Antigen Region | 16-45 aa |
| Gene ID | 4071 |
|---|---|
| Other Names | Transmembrane 4 L6 family member 1, Membrane component chromosome 3 surface marker 1, Tumor-associated antigen L6, TM4SF1, M3S1, TAAL6 |
| Target/Specificity | This TM4SF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-45 amino acids from the N-terminal region of human TM4SF1. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TM4SF1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TM4SF1 |
|---|---|
| Synonyms | M3S1, TAAL6 |
| Cellular Location | Membrane; Multi-pass membrane protein. Note=Colocalizes with SDCBP2 in the apical region of the cell (PubMed:11102519). |
| Tissue Location | Highly expressed in lung, breast, colon and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular |
Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas.
References
Gordon, G.J., et al. J. Natl. Cancer Inst. 101(9):678-686(2009)
Lekishvili, T., et al. J. Cell. Sci. 121 (PT 5), 685-694 (2008) :
Stelzl, U., et al. Cell 122(6):957-968(2005)
Chang, Y.W., et al. Int. J. Cancer 116(2):243-252(2005)
Kao, Y.R., et al. Clin. Cancer Res. 9(7):2807-2816(2003)
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