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KRT12 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 2
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, FC, E |
|---|---|
| Primary Accession | Q99456 |
| Other Accession | NP_000214.1 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 53511 Da |
| Antigen Region | 442-471 aa |
| Gene ID | 3859 |
|---|---|
| Other Names | Keratin, type I cytoskeletal 12, Cytokeratin-12, CK-12, Keratin-12, K12, KRT12 |
| Target/Specificity | This KRT12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 442-471 amino acids from the C-terminal region of human KRT12. |
| Dilution | WB~~1:2000 IHC-P~~1:10~50 FC~~1:25 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KRT12 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KRT12 |
|---|---|
| Function | Involved in corneal epithelium organization, integrity and corneal keratin expression. |
| Tissue Location | Expressed in the corneal epithelium (at protein level). |
Provided below are standard protocols that you may find useful for product applications.
Background
KRT12 encodes the type I intermediate filament chain keratin 12, expressed in corneal epithelia. Mutations in this gene lead to Meesmann corneal dystrophy.
References
Clausen, I., et al. Mol. Vis. 16, 954-960 (2010) :
Seto, T., et al. Jpn. J. Ophthalmol. 52(3):224-226(2008)
Nielsen, K., et al. Cornea 27(1):100-102(2008)
Sullivan, L.S., et al. Mol. Vis. 13, 975-980 (2007) :
Schweizer, J., et al. J. Cell Biol. 174(2):169-174(2006)
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