WHSC1L1 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9BZ95 |
Other Accession | NP_060248.2, NP_075447.1 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 161613 Da |
Antigen Region | 188-217 aa |
Gene ID | 54904 |
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Other Names | Histone-lysine N-methyltransferase NSD3, Nuclear SET domain-containing protein 3, Protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1, WHSC1-like protein 1, WHSC1L1, NSD3 |
Target/Specificity | This WHSC1L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 188-217 amino acids from the N-terminal region of human WHSC1L1. |
Dilution | WB~~1:2000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | WHSC1L1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NSD3 (HGNC:12767) |
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Synonyms | WHSC1L1 |
Function | Histone methyltransferase. Preferentially dimethylates 'Lys- 4' and 'Lys-27' of histone H3 forming H3K2me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. |
Cellular Location | Nucleus. Chromosome. |
Tissue Location | Highly expressed in brain, heart and skeletal muscle. Expressed at lower level in liver and lung |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. The function of the protein has not been determined. Two alternatively spliced variants have been described.
References
Zhou, Z., et al. Biochem. Biophys. Res. Commun. 398(3):565-570(2010)
Kim, S.M., et al. Biochem. Biophys. Res. Commun. 345(1):318-323(2006)
Tonon, G., et al. Proc. Natl. Acad. Sci. U.S.A. 102(27):9625-9630(2005)
Rosati, R., et al. Blood 99(10):3857-3860(2002)
Stec, I., et al. Genomics 76 (1-3), 5-8 (2001) :
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