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GCDH Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q92947 |
| Other Accession | Q8HXX8, Q2KHZ9, NP_000150.1, NP_039663.1 |
| Reactivity | Human |
| Predicted | Bovine, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 48127 Da |
| Antigen Region | 336-365 aa |
| Gene ID | 2639 |
|---|---|
| Other Names | Glutaryl-CoA dehydrogenase, mitochondrial, GCD, GCDH |
| Target/Specificity | This GCDH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-365 amino acids from the C-terminal region of human GCDH. |
| Dilution | IHC-P~~1:10~50 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GCDH Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GCDH |
|---|---|
| Function | Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L- hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive. |
| Cellular Location | Mitochondrion matrix. |
| Tissue Location | Isoform Long and isoform Short are expressed in fibroblasts and liver |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Park, J.D., et al. J. Korean Med. Sci. 25(6):957-960(2010)
Strauss, K.A., et al. Brain 133 (PT 1), 76-92 (2010) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Ganesh, S.K., et al. Nat. Genet. 41(11):1191-1198(2009)
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