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ZCRB1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | Q8TBF4 |
| Other Accession | Q6DJI9, Q56JZ7, NP_149105.3 |
| Reactivity | Human, Mouse |
| Predicted | Bovine, Xenopus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 24592 Da |
| Antigen Region | 184-212 aa |
| Gene ID | 85437 |
|---|---|
| Other Names | Zinc finger CCHC-type and RNA-binding motif-containing protein 1, U11/U12 small nuclear ribonucleoprotein 31 kDa protein, U11/U12 snRNP 31 kDa protein, U11/U12-31K, ZCRB1 |
| Target/Specificity | This ZCRB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 184-212 amino acids from the C-terminal region of human ZCRB1. |
| Dilution | FC~~1:10~50 IHC-P~~1:10~50 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ZCRB1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZCRB1 |
|---|---|
| Cellular Location | Nucleus, nucleoplasm |
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Provided below are standard protocols that you may find useful for product applications.
Background
Pre-mRNA splicing is catalyzed by the spliceosome. U12-type spliceosome binds U12-type pre-mRNAs and recognizes the 5' splice site and branch-point sequence. U11 and U12 snRNPs are components of U12-type spliceosome and function as a molecular bridge connecting both ends of the intron. The protein encoded by this gene contains a RNA recognition motif. It was identified as one of the protein components of U11/U12 snRNPs. This protein and many other U11/U12 snRNP proteins are highly conserved in organisms known to contain U12-type introns. These proteins have been shown to be essential for cell viability, suggesting the key roles in U12-type splicing.
References
Wang, H., et al. Genomics 89(1):59-69(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Will, C.L., et al. RNA 10(6):929-941(2004)
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