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FPR3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P25089 |
| Other Accession | NP_002021.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 39965 Da |
| Antigen Region | 322-351 aa |
| Gene ID | 2359 |
|---|---|
| Other Names | N-formyl peptide receptor 3, FMLP-related receptor II, FMLP-R-II, Formyl peptide receptor-like 2, FPR3, FPRH1, FPRL2 |
| Target/Specificity | This FPR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 322-351 amino acids from the C-terminal region of human FPR3. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FPR3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FPR3 |
|---|---|
| Synonyms | FPRH1, FPRL2 |
| Function | Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Acts as a receptor for humanin (PubMed:15465011). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Location | Detected in various tissues with highest expression in lung. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.
References
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Kim, S.D., et al. J. Immunol. 183(9):5511-5517(2009)
Devosse, T., et al. J. Immunol. 182(8):4974-4984(2009)
Lambert, N.A. Sci Signal 1 (25), RE5 (2008) :
Lee, H.Y., et al. Biochem. Biophys. Res. Commun. 359(4):985-990(2007)
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