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PITPNB Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P48739 |
| Other Accession | P53812, P53811, Q9TR36, NP_036531.1 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 31540 Da |
| Antigen Region | 226-254 aa |
| Gene ID | 23760 |
|---|---|
| Other Names | Phosphatidylinositol transfer protein beta isoform, PI-TP-beta, PtdIns transfer protein beta, PtdInsTP beta, PITPNB |
| Target/Specificity | This PITPNB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 226-254 amino acids from the C-terminal region of human PITPNB. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PITPNB Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PITPNB |
|---|---|
| Function | Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (PubMed:10531358, PubMed:18636990, PubMed:20332109). Also catalyzes the transfer of sphingomyelin (By similarity). Required for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum; phosphatidylinositol and phosphatidylcholine transfer activity is essential for this function (PubMed:20332109). |
| Cellular Location | Golgi apparatus {ECO:0000250|UniProtKB:P53811}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P53812}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P53812} |
| Tissue Location | Widely expressed in various tissues including brain |
Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is found in the cytoplasm, where it catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes.
References
Carvou, N., et al. J. Cell. Sci. 123 (PT 8), 1262-1273 (2010) :
Morgan, C.P., et al. Biochem. J. 398(3):411-421(2006)
Colland, F., et al. Genome Res. 14(7):1324-1332(2004)
Collins, J.E., et al. Genome Biol. 5 (10), R84 (2004) :
Segui, B., et al. Biochem. J. 366 (PT 1), 23-34 (2002) :
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