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LNX2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q8N448 |
| Other Accession | NP_699202.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 76004 Da |
| Antigen Region | 551-579 aa |
| Gene ID | 222484 |
|---|---|
| Other Names | Ligand of Numb protein X 2, Numb-binding protein 2, PDZ domain-containing RING finger protein 1, LNX2, PDZRN1 |
| Target/Specificity | This LNX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 551-579 amino acids from the C-terminal region of human LNX2. |
| Dilution | IHC-P~~1:10~50 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LNX2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LNX2 |
|---|---|
| Synonyms | PDZRN1 |
Provided below are standard protocols that you may find useful for product applications.
Background
LNX2 (Ligand of numb-protein X 2) is a multimodular protein that binds to NUMB via the NPXY motif. It may serve as a molecular scaffold that localizes unrelated, interacting proteins, such as NUMB, to specific subcellular sites.
References
Thorleifsson, G., et al. Nat. Genet. 41(1):18-24(2009)
Sullivan, P.F., et al. Mol. Psychiatry 13(6):570-584(2008)
Dunham, A., et al. Nature 428(6982):522-528(2004)
Rice, D.S., et al. Mol. Cell. Neurosci. 18(5):525-540(2001)
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