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PR15B Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q5SWA1 |
| Other Accession | NP_116222.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 79125 Da |
| Antigen Region | 494-522 aa |
| Gene ID | 84919 |
|---|---|
| Other Names | Protein phosphatase 1 regulatory subunit 15B, PPP1R15B |
| Target/Specificity | This PR15B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 494-522 amino acids from the C-terminal region of human PR15B. |
| Dilution | IHC-P~~1:10~50 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PR15B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PPP1R15B |
|---|---|
| Function | Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
PPP1R15B promotes dephosphorylation of the transcription initiation factor EIF2-alpha (EIF2S1; MIM 603907) through recruitment of protein phosphatase-1 (PP1) catalytic subunits (see MIM 176875) (Harding et al., 2009 [PubMed 19181853]).[supplied by OMIM].
References
Harding, H.P., et al. Proc. Natl. Acad. Sci. U.S.A. 106(6):1832-1837(2009)
Colland, F., et al. Genome Res. 14(7):1324-1332(2004)
Ceulemans, H., et al. Bioessays 24(4):371-381(2002)
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