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PYDC1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8WXC3 |
| Other Accession | NP_690865.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 10107 Da |
| Antigen Region | 13-42 aa |
| Gene ID | 260434 |
|---|---|
| Other Names | Pyrin domain-containing protein 1, PAAD-only protein 1, Pyrin-only protein 1, PYDC1, ASC2, ASCI, POP1, PYC1 |
| Target/Specificity | This PYDC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-42 amino acids from the Central region of human PYDC1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PYDC1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PYDC1 (HGNC:30261) |
|---|---|
| Function | Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro- caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS. |
| Cellular Location | Cytoplasm. Note=Recruited to specks formed by PYCARD within the cytoplasm |
| Tissue Location | Predominantly expressed in monocytes, macrophages and granulocytes. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
PYDC1 associates with apoptosis-associated specklike protein containing a CARD domain (ASC) and modulates its ability to collaborate with pyrin and cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.
References
Son, Y.L., et al. Biochem. J. 410(2):319-330(2008)
Natarajan, A., et al. J. Biol. Chem. 281(42):31863-31875(2006)
Espejo, F., et al. Biochem. Biophys. Res. Commun. 340(3):860-864(2006)
Stehlik, C., et al. Biochem. J. 373 (PT 1), 101-113 (2003) :
Pawlowski, K., et al. Trends Biochem. Sci. 26(2):85-87(2001)
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