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TRIM38 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | O00635 |
| Other Accession | Q58DK8, NP_006346.1 |
| Reactivity | Human |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 53416 Da |
| Antigen Region | 423-451 aa |
| Gene ID | 10475 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase TRIM38, 632-, RING finger protein 15, Tripartite motif-containing protein 38, Zinc finger protein RoRet, TRIM38, RNF15, RORET |
| Target/Specificity | This TRIM38 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 423-451 amino acids from the C-terminal region of human TRIM38. |
| Dilution | FC~~1:10~50 IHC-P~~1:10~50 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TRIM38 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRIM38 {ECO:0000303|PubMed:23056470, ECO:0000312|HGNC:HGNC:10059} |
|---|---|
| Function | E3 ubiquitin-protein and E3 SUMO-protein ligase that acts as a regulator of innate immunity (PubMed:23056470). Acts as a negative regulator of type I interferon IFN-beta production by catalyzing 'Lys- 48'-linked polyubiquitination of AZI2/NAP1, leading to its degradation (By similarity). Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling (PubMed:23056470). Acts as positive regulator of the cGAS-STING pathway by acting as a E3 SUMO- protein ligase: mediates sumoylation of CGAS and STING, preventing their degradation and thereby activating the innate immune response to DNA virus (By similarity). Also acts as a negative regulator of NF- kappa-B signaling independently of its E3 protein ligase activity by promoting lysosome-dependent degradation of TAB2 and TAB3 adapters (PubMed:24434549). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q5SZ99}. |
| Tissue Location | Ubiquitous.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified.
References
Benyamin, B., et al. Am. J. Hum. Genet. 84(1):60-65(2009)
Matsuda, A., et al. Oncogene 22(21):3307-3318(2003)
Chen, D., et al. J. Biol. Chem. 277(18):15985-15991(2002)
Reymond, A., et al. EMBO J. 20(9):2140-2151(2001)
Ruddy, D.A., et al. Genome Res. 7(5):441-456(1997)
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