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Anti-TRIM38 Antibody
Rabbit polyclonal antibody to TRIM38
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- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | O00635 |
| Reactivity | Human, Mouse, Rat, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 53416 Da |
| Gene ID | 10475 |
|---|---|
| Other Names | RNF15; RORET; Tripartite motif-containing protein 38; RING finger protein 15; Zinc finger protein RoRet |
| Target/Specificity | Recognizes endogenous levels of TRIM38 protein. |
| Dilution | WB~~WB (1/500 - 1/1000) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | TRIM38 {ECO:0000303|PubMed:23056470, ECO:0000312|HGNC:HGNC:10059} |
|---|---|
| Function | E3 ubiquitin-protein and E3 SUMO-protein ligase that acts as a regulator of innate immunity (PubMed:23056470). Acts as a negative regulator of type I interferon IFN-beta production by catalyzing 'Lys- 48'-linked polyubiquitination of AZI2/NAP1, leading to its degradation (By similarity). Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling (PubMed:23056470). Acts as positive regulator of the cGAS-STING pathway by acting as a E3 SUMO- protein ligase: mediates sumoylation of CGAS and STING, preventing their degradation and thereby activating the innate immune response to DNA virus (By similarity). Also acts as a negative regulator of NF- kappa-B signaling independently of its E3 protein ligase activity by promoting lysosome-dependent degradation of TAB2 and TAB3 adapters (PubMed:24434549). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q5SZ99}. |
| Tissue Location | Ubiquitous.. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human TRIM38. The exact sequence is proprietary.
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