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SFRS2B Antibody (N-term )
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BRL6 |
| Other Accession | NP_115285.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 32288 Da |
| Antigen Region | 45-73 aa |
| Gene ID | 10929 |
|---|---|
| Other Names | Serine/arginine-rich splicing factor 8, Pre-mRNA-splicing factor SRP46, Splicing factor SRp46, Splicing factor, arginine/serine-rich 2B, SRSF8, SFRS2B, SRP46 |
| Target/Specificity | This SFRS2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-73 amino acids from the N-terminal region of human SFRS2B. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SFRS2B Antibody (N-term ) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SRSF8 |
|---|---|
| Synonyms | SFRS2B, SRP46 |
| Function | Involved in pre-mRNA alternative splicing. |
| Cellular Location | Nucleus. |
| Tissue Location | Strongly expressed in pancreas, spleen and prostate. Weakly expressed in lung, liver and thymus |
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Provided below are standard protocols that you may find useful for product applications.
Background
The SR (serine/arginine-rich) family contains a number of phosphoproteins that function as essential and alternative splicing factors. The SR family of proteins is characterized by the presence of a ribonucleoprotein (RNP)-type RNA binding motif and a carboxyl-terminal arginine-serine-rich (RS) domain. The protein encoded by this gene is a member of the SR family and functions as an essential splicing factor in vitro. This gene is thought to be an expressed PR264/SC35 retropseudogene.
References
Manley, J.L., et al. Genes Dev. 24(11):1073-1074(2010)
Lareau, L.F., et al. Nature 446(7138):926-929(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Li, J., et al. Mol. Cell. Biol. 23(21):7437-7447(2003)
Grottke, C., et al. Int. J. Cancer 88(4):535-546(2000)
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