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KCNS2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9ULS6 |
| Other Accession | Q9ER26, O35174, NP_065748.1 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 54237 Da |
| Antigen Region | 111-140 aa |
| Gene ID | 3788 |
|---|---|
| Other Names | Potassium voltage-gated channel subfamily S member 2, Delayed-rectifier K(+) channel alpha subunit 2, Voltage-gated potassium channel subunit Kv92, KCNS2, KIAA1144 |
| Target/Specificity | This KCNS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-140 amino acids from the N-terminal region of human KCNS2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KCNS2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KCNS2 (HGNC:6301) |
|---|---|
| Synonyms | KIAA1144 |
| Function | Potassium channel regulatory subunit that modulate the delayed rectifier voltage-gated potassium channel activity of KCNB1 and KCNB2 by altering their kinetics, expression levels, and shifting the half-inactivation potential to more polarized values. While it does not form functional channels on its own, it can form functional heterotetrameric channels with KCNB1 and KCNB2. Each regulatory subunit has unique regulatory properties that can lead to extensive inhibition, significant changes in kinetics, and/or substantial shifts in the voltage dependencies of the inactivation process. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:O35174}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O35174}. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 or KCNB2 {ECO:0000250|UniProtKB:O35174} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
KCNS2 is potassium channel subunit. It modulates channel activity and reduces the ion flow (By similarity).
References
Gutman, G.A., et al. Pharmacol. Rev. 57(4):473-508(2005)
Salinas, M., et al. J. Biol. Chem. 272(39):24371-24379(1997)
Banfi, S., et al. Nat. Genet. 13(2):167-174(1996)
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