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MORC1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q86VD1 |
| Other Accession | NP_055244.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 112881 Da |
| Antigen Region | 892-921 aa |
| Gene ID | 27136 |
|---|---|
| Other Names | MORC family CW-type zinc finger protein 1, Cancer/testis antigen 33, CT33, MORC1 {ECO:0000312|EMBL:AAH503071} |
| Target/Specificity | This MORC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 892-921 amino acids from the C-terminal region of human MORC1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MORC1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MORC1 {ECO:0000312|EMBL:AAH50307.1} |
|---|---|
| Function | Required for spermatogenesis (By similarity). Essential for de novo DNA methylation and silencing of transposable elements in the male embryonic germ cells (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q9WVL5}. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes the human homolog of mouse morc and like the mouse protein it is testis-specific. Mouse studies support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent defect. These studies further support a role for this protein early in spermatogenesis, possibly by affecting entry into apoptosis because testis from knockout mice show greatly increased numbers of apoptotic cells.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Inoue, N., et al. Cytogenet. Cell Genet. 90 (1-2), 123-125 (2000) :
Inoue, N., et al. Hum. Mol. Genet. 8(7):1201-1207(1999)
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