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TNN Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q9UQP3 |
| Other Accession | NP_071376.1 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 144034 Da |
| Antigen Region | 587-615 aa |
| Gene ID | 63923 |
|---|---|
| Other Names | Tenascin-N, TN-N, TNN |
| Target/Specificity | This TNN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 587-615 amino acids from the Central region of human TNN. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TNN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TNN (HGNC:22942) |
|---|---|
| Function | Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (By similarity) (PubMed:17909022). Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity). During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling (By similarity). In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells (PubMed:17909022). |
| Cellular Location | Secreted, extracellular space, extracellular matrix |
| Tissue Location | Not detected in normal adult mammary tissues or brain but expressed in most breast tumors and brain tumors, such as glioblastomas, astrocytomas and oligodendrogliomas, tested (PubMed:17909022, PubMed:19884327). In brain tumors, detected around the endothelial cell layer of the clood vessels (PubMed:19884327) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
TNN is involved in neurite outgrowth and cell migration in hippocampal explants (By similarity).
References
Gylfe, A.E., et al. Int. J. Cancer (2010) In press :
Degen, M., et al. Int. J. Cancer 122(11):2454-2461(2008)
Degen, M., et al. Cancer Res. 67(19):9169-9179(2007)
Liu, T., et al. J. Proteome Res. 4(6):2070-2080(2005)
Scherberich, A., et al. Oncogene 24(9):1525-1532(2005)
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