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TNN Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - TNN Antibody (Center) AP13618C
    TNN Antibody (Center) (Cat. #AP13618c) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the TNN antibody detected the TNN protein (arrow).
    detail
  • IHC-P - TNN Antibody (Center) AP13618C
    TNN Antibody (Center) (Cat. #AP13618c)immunohistochemistry analysis in formalin fixed and paraffin embedded human uterus tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TNN Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, WB, E
Primary Accession Q9UQP3
Other Accession NP_071376.1
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 144034 Da
Antigen Region 587-615 aa
Additional Information
Gene ID 63923
Other Names Tenascin-N, TN-N, TNN
Target/Specificity This TNN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 587-615 amino acids from the Central region of human TNN.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTNN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNN (HGNC:22942)
Function Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (By similarity) (PubMed:17909022). Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity). During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling (By similarity). In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells (PubMed:17909022).
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Not detected in normal adult mammary tissues or brain but expressed in most breast tumors and brain tumors, such as glioblastomas, astrocytomas and oligodendrogliomas, tested (PubMed:17909022, PubMed:19884327). In brain tumors, detected around the endothelial cell layer of the clood vessels (PubMed:19884327)
Research Areas
Citations (0)
citation

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Background

TNN is involved in neurite outgrowth and cell migration in hippocampal explants (By similarity).

References

Gylfe, A.E., et al. Int. J. Cancer (2010) In press :
Degen, M., et al. Int. J. Cancer 122(11):2454-2461(2008)
Degen, M., et al. Cancer Res. 67(19):9169-9179(2007)
Liu, T., et al. J. Proteome Res. 4(6):2070-2080(2005)
Scherberich, A., et al. Oncogene 24(9):1525-1532(2005)

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$ 365.00
$ 140.00
Cat# AP13618C
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