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ARHGDIB Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | P52566 |
| Other Accession | NP_001166.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 22988 Da |
| Antigen Region | 160-188 aa |
| Gene ID | 397 |
|---|---|
| Other Names | Rho GDP-dissociation inhibitor 2, Rho GDI 2, Ly-GDI, Rho-GDI beta, ARHGDIB, GDIA2, GDID4, RAP1GN1 |
| Target/Specificity | This ARHGDIB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-188 amino acids from the C-terminal region of human ARHGDIB. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ARHGDIB Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ARHGDIB |
|---|---|
| Synonyms | GDIA2, GDID4, RAP1GN1 |
| Function | Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:8356058, PubMed:7512369). Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed:8262133). |
| Cellular Location | Cytoplasm, cytosol. |
| Tissue Location | Detected in bone marrow, thymus and spleen. |
Provided below are standard protocols that you may find useful for product applications.
Background
Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).
References
Niu, H., et al. Oncol. Rep. 24(2):465-471(2010)
Zhen, H., et al. Int. J. Gynecol. Cancer 20(3):316-322(2010)
Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)
Said, N., et al. Cancer Metastasis Rev. 28 (3-4), 327-333 (2009) :
Hosgood, H.D. III, et al. Respir Med 103(12):1866-1870(2009)
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