PNPLA4 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | P41247 |
Other Accession | NP_004641.1, NP_001135861.1, NP_001166143.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 27980 Da |
Antigen Region | 171-199 aa |
Gene ID | 8228 |
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Other Names | Patatin-like phospholipase domain-containing protein 4, Protein GS2, PNPLA4, DXS1283E, GS2 |
Target/Specificity | This PNPLA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 171-199 amino acids from the C-terminal region of human PNPLA4. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PNPLA4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PNPLA4 (HGNC:24887) |
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Function | Has abundant triacylglycerol lipase activity (PubMed:15364929, PubMed:16150821, PubMed:17603008). Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides (PubMed:17603008). Additionally possesses acylglycerol transacylase and phospholipase A2 activities (PubMed:15364929, PubMed:17603008). |
Cellular Location | Mitochondrion. |
Tissue Location | Expressed in all tissues examined, including heart, brain, placenta, lung, liver, muscle, kidney, pancreas and spleen |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the patatin-like family of phospholipases. The encoded enzyme has both triacylglycerol lipase and transacylase activities and may be involved in adipocyte triglyceride homeostasis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome Y.
References
Gao, J.G., et al. Mol. Genet. Metab. 96(4):253-260(2009)
Kienesberger, P.C., et al. J. Lipid Res. 50 SUPPL, S63-S68 (2009) :
Johansson, L.E., et al. PLoS ONE 4 (4), E5327 (2009) :
Gao, J.G., et al. Biochem. Biophys. Res. Commun. 360(2):501-506(2007)
Wilson, P.A., et al. J. Lipid Res. 47(9):1940-1949(2006)
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