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HTRA3 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P83110 |
| Other Accession | NP_444272.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 48608 Da |
| Antigen Region | 262-290 aa |
| Gene ID | 94031 |
|---|---|
| Other Names | Serine protease HTRA3, 3421-, High-temperature requirement factor A3, Pregnancy-related serine protease, HTRA3, PRSP |
| Target/Specificity | This HTRA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 262-290 amino acids from the Central region of human HTRA3. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HTRA3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HTRA3 |
|---|---|
| Synonyms | PRSP |
| Function | Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF- beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (PubMed:21321049, PubMed:22229724). |
| Cellular Location | Secreted. Note=Secretion increased during decidualization of endometrial stromal cells |
| Tissue Location | Widely expressed, with highest levels in both adult and fetal heart, ovary, uterus placenta, and bladder. In the endometrium, expressed in epithelial glands and the stroma. Also present in leukocytes. Isoform 1 is predominant in heart and skeletal muscle, whereas isoform 2 is predominant in placenta and kidney |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
HTRA3 is probable serine protease.
References
Zurawa-Janicka, D., et al. Expert Opin. Ther. Targets 14(7):665-679(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Beleford, D., et al. J. Biol. Chem. 285(16):12011-12027(2010)
Theoleyre, S., et al. Biochem. Biophys. Res. Commun. 394(3):453-458(2010)
Beleford, D., et al. Clin. Cancer Res. 16(2):398-409(2010)
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