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BRD1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | O95696 |
| Other Accession | NP_055392.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 119520 Da |
| Antigen Region | 73-102 aa |
| Gene ID | 23774 |
|---|---|
| Other Names | Bromodomain-containing protein 1, BR140-like protein, Bromodomain and PHD finger-containing protein 2, BRD1, BRL, BRPF2 |
| Target/Specificity | This BRD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 73-102 amino acids from the N-terminal region of human BRD1. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | BRD1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BRD1 {ECO:0000303|PubMed:16387653, ECO:0000312|HGNC:HGNC:1102} |
|---|---|
| Function | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:16387653, PubMed:21753189, PubMed:21880731). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation (PubMed:21753189). |
| Cellular Location | Nucleus. Chromosome Note=Localizes to transcription start sites |
| Tissue Location | Highly expressed in testis. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein of unknown function. The protein contains a bromodomain, a sequence motif often found in transcriptional coactivators, and localizes to the nucleus in testis and several other cell types.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Kushima, I., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (3), 786-791 (2010) :
Nyegaard, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (2), 582-591 (2010) :
Bjarkam, C.R., et al. Brain Struct Funct 214(1):37-47(2009)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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