HCLS1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | P14317 |
Other Accession | NP_005326.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 54014 Da |
Antigen Region | 362-391 aa |
Gene ID | 3059 |
---|---|
Other Names | Hematopoietic lineage cell-specific protein, Hematopoietic cell-specific LYN substrate 1, LckBP1, p75, HCLS1, HS1 |
Target/Specificity | This HCLS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 362-391 amino acids from the C-terminal region of human HCLS1. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | HCLS1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | HCLS1 |
---|---|
Synonyms | HS1 |
Function | Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. |
Cellular Location | Membrane; Peripheral membrane protein. Cytoplasm. Mitochondrion |
Tissue Location | Expressed only in tissues and cells of hematopoietic origin |
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Provided below are standard protocols that you may find useful for product applications.
Background
Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.
References
Muzio, M., et al. Leukemia 21(9):2067-2070(2007)
Lim, J., et al. Cell 125(4):801-814(2006)
Hao, J.J., et al. J. Biol. Chem. 280(45):37988-37994(2005)
Tao, W.A., et al. Nat. Methods 2(8):591-598(2005)
Brunati, A.M., et al. J. Biol. Chem. 280(22):21029-21035(2005)
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