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UBP1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, IHC-P, E |
|---|---|
| Primary Accession | Q9NZI7 |
| Other Accession | Q811S7, NP_001121632.1, NP_055332.3, NP_001121633.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 60491 Da |
| Antigen Region | 266-295 aa |
| Gene ID | 7342 |
|---|---|
| Other Names | Upstream-binding protein 1, Transcription factor LBP-1, UBP1, LBP1 |
| Target/Specificity | This UBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 266-295 amino acids from the Central region of human UBP1. |
| Dilution | WB~~1:1000 IF~~1:10~50 IHC-P~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | UBP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | UBP1 |
|---|---|
| Synonyms | LBP1 |
| Function | Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA- box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box. |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed in adrenal tissue, JEG-3, NCI-H295A, Hep- G2 and HeLa cell lines. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
UBP1 functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box.
References
Katsura, A., et al. Genes Cells 14(10):1183-1196(2009)
Koutnikova, H., et al. PLoS Genet. 5 (8), E1000591 (2009) :
Henderson, Y.C., et al. DNA Cell Biol. 27(2):71-79(2008)
Huang, N., et al. Mol. Endocrinol. 19(2):409-420(2005)
Huang, N., et al. J. Biol. Chem. 275(4):2852-2858(2000)
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