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AES Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q08117 |
| Other Accession | NP_001121.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 21970 Da |
| Antigen Region | 156-184 aa |
| Gene ID | 166 |
|---|---|
| Other Names | Amino-terminal enhancer of split, Amino enhancer of split, Gp130-associated protein GAM, Grg-5, Groucho-related protein 5, Protein ESP1, Protein GRG, AES, GRG, GRG5 |
| Target/Specificity | This AES antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-184 amino acids from the C-terminal region of human AES. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | AES Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TLE5 (HGNC:307) |
|---|---|
| Synonyms | AES, GRG, GRG5 |
| Function | Transcriptional corepressor. Acts as a dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development. |
| Cellular Location | Nucleus. |
| Tissue Location | Found predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
References
Zhang, Y., et al. Biochem. J. 427(3):499-511(2010)
Beagle, B., et al. PLoS ONE 5 (7), E11821 (2010) :
Arce, L., et al. BMC Cancer 9, 159 (2009) :
Zhang, X., et al. J. Neurosci. Res. 86(11):2423-2431(2008)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
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