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AES / Groucho Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, ICC |
|---|---|
| Primary Accession | Q08117 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 22kDa |
| Dilution | IHC-P (2.5 µg/ml), WB (1-2 µg/ml), |
| Gene ID | 166 |
|---|---|
| Other Names | Amino-terminal enhancer of split, Amino enhancer of split, Gp130-associated protein GAM, Grg-5, Groucho-related protein 5, Protein ESP1, Protein GRG, AES, GRG, GRG5 |
| Target/Specificity | 16 amino acid peptide from near the carboxy terminus of human AES |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | AES / Groucho Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TLE5 (HGNC:307) |
|---|---|
| Synonyms | AES, GRG, GRG5 |
| Function | Transcriptional corepressor. Acts as a dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development. |
| Cellular Location | Nucleus. |
| Tissue Location | Found predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development.
References
Scala L.A.,et al.Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases.
Hou E.W.,et al.DNA Cell Biol. 17:911-913(1998).
Liu Y.,et al.Zhonghua Wei Sheng Wu Xue He Mian Yi Xue Za Zhi 18:106-110(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Grimwood J.,et al.Nature 428:529-535(2004).
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