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Mouse Map3k14 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9WUL6 |
| Other Accession | NP_058592.1 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 103080 Da |
| Antigen Region | 652-680 aa |
| Gene ID | 53859 |
|---|---|
| Other Names | Mitogen-activated protein kinase kinase kinase 14, NF-kappa-beta-inducing kinase, Serine/threonine-protein kinase NIK, Map3k14, Nik |
| Target/Specificity | This Mouse Map3k14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 652-680 amino acids from the C-terminal region of mouse Map3k14. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Map3k14 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Map3k14 {ECO:0000312|MGI:MGI:1858204} |
|---|---|
| Function | Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Phosphorylates CHUK/IKKA (By similarity). Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway (PubMed:11239468). Has an essential role in the non-canonical NF-kappa- B signalining that regulates genes encoding molecules involved in B- cell survival, lymphoid organogenesis, and immune response (By similarity). Could act in a receptor-selective manner. |
| Cellular Location | Cytoplasm. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.
References
Bhattacharyya, S., et al. Exp. Cell Res. 316(19):3317-3327(2010)
Maeda, Y., et al. Int. Immunol. 22(6):515-525(2010)
Sanjo, H., et al. J. Biol. Chem. 285(22):17148-17155(2010)
Takeshima, T., et al. Cancer Res. 70(7):2697-2706(2010)
Moro, K., et al. Nature 463(7280):540-544(2010)
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