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TACR3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P29371 |
| Other Accession | NP_001050.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 52202 Da |
| Antigen Region | 406-435 aa |
| Gene ID | 6870 |
|---|---|
| Other Names | Neuromedin-K receptor, NKR, NK-3 receptor, NK-3R, Neurokinin B receptor, Tachykinin receptor 3, TACR3, NK3R, TAC3R |
| Target/Specificity | This TACR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 406-435 amino acids from the C-terminal region of human TACR3. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TACR3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TACR3 |
|---|---|
| Synonyms | NK3R, TAC3R |
| Function | This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B.
References
Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010)
Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)
Gianetti, E., et al. J. Clin. Endocrinol. Metab. 95(6):2857-2867(2010)
Young, J., et al. J. Clin. Endocrinol. Metab. 95(5):2287-2295(2010)
Fukami, M., et al. Horm Res Paediatr 73(6):477-481(2010)
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