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PPYR1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P50391 |
| Other Accession | NP_005963.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 42142 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 100996758;5540 |
|---|---|
| Other Names | Neuropeptide Y receptor type 4, NPY4-R, Pancreatic polypeptide receptor 1, PP1, NPY4R, PPYR1 |
| Target/Specificity | This PPYR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PPYR1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PPYR1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NPY4R |
|---|---|
| Synonyms | PPYR1 |
| Function | G protein-coupled receptor for PPY/pancreatic polypeptide/PP, NPY/neuropeptide Y and PYY/peptide YY that is negatively coupled to cAMP (PubMed:7493937, PubMed:7592911). The rank order of affinity for these polypeptides and their derivatives is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid. |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Highest levels found in brain, coronary artery and ileum. Low levels in pancreas and kidney. Detected in colon and small intestine. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Umeda, T., et al. Peptides 30(8):1441-1447(2009)
Sha, B.Y., et al. J. Hum. Genet. 54(4):199-202(2009)
Gao, Y., et al. Biochemistry 47(43):11367-11376(2008)
Parker, E., et al. Eur. J. Pharmacol. 440 (2-3), 173-187 (2002) :
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