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CCDC50 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q8IVM0 |
| Other Accession | Q810U0, Q810U5, NP_777568.1, NP_848018.1 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 35822 Da |
| Antigen Region | 86-114 aa |
| Gene ID | 152137 |
|---|---|
| Other Names | Coiled-coil domain-containing protein 50, Protein Ymer, CCDC50, C3orf6 |
| Target/Specificity | This CCDC50 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-114 amino acids from the Central region of human CCDC50. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CCDC50 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CCDC50 |
|---|---|
| Synonyms | C3orf6 |
| Function | Involved in EGFR signaling. |
| Cellular Location | Cytoplasm. Note=Associated with microtubules of the cytoskeleton and mitotic apparatus. |
| Tissue Location | Isoform 1 and isoform 2 are coexpressed in placenta, liver, lung, kidney and pancreas. Only isoform 1 is detected in skeletal muscle, brain and heart. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a soluble, cytoplasmic, tyrosine-phosphorylated protein with multiple ubiquitin-interacting domains. Mutations in this gene cause nonsyndromic, postlingual, progressive sensorineural DFNA44 hearing loss. In mouse, the protein is expressed in the inner ear during development and postnatal maturation and associates with microtubule-based structures. This protein may also function as a negative regulator of NF-kB signaling and as an effector of epidermal growth factor (EGF)-mediated cell signaling. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq].
References
Farfsing, A., et al. Leukemia 23(11):2018-2026(2009)
Kameda, H., et al. Biochem. Biophys. Res. Commun. 378(4):744-749(2009)
Bohgaki, M., et al. Biochim. Biophys. Acta 1783(5):826-837(2008)
Modamio-Hoybjor, S., et al. Am. J. Hum. Genet. 80(6):1076-1089(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
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