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Mouse Tssk6 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q925K9 |
| Other Accession | NP_114393.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 30287 Da |
| Antigen Region | 204-232 aa |
| Gene ID | 83984 |
|---|---|
| Other Names | Testis-specific serine/threonine-protein kinase 6, TSK-6, TSSK-6, Testis-specific kinase 6, Serine/threonine-protein kinase SSTK, Small serine/threonine kinase, Tssk6 {ECO:0000312|MGI:MGI:2148775} |
| Target/Specificity | This Mouse Tssk6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 204-232 amino acids from the C-terminal region of mouse Tssk6. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Tssk6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Tssk6 {ECO:0000303|PubMed:28389581, ECO:0000312|MGI:MGI:2148775} |
|---|---|
| Function | Serine/threonine-protein kinase component of the sperm flagellar doublet microtubules (PubMed:15870294, PubMed:37295417). May act as a regulator of sperm motility by mediating phosphorylation of sperm doublet microtubule proteins (PubMed:37295417). Plays a role in DNA condensation during postmeiotic chromatin remodeling and histone- to-protamine transition during spermatogenesis (PubMed:15870294, PubMed:28389581). |
| Cellular Location | Cytoplasm, cytoskeleton, flagellum axoneme. Nucleus Note=Component of the sperm flagellar doublet microtubules (PubMed:37295417). Also localizes in the nucleus of elongating spermatids (PubMed:28389581). |
| Tissue Location | Expressed in the testis, localized to the heads of elongating spermatids. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Tssk6 is required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling.
References
Jha, K.N., et al. J. Biol. Chem. 285(45):35180-35187(2010)
Sosnik, J., et al. J. Cell. Sci. 122 (PT 15), 2741-2749 (2009) :
Spiridonov, N.A., et al. Mol. Cell. Biol. 25(10):4250-4261(2005)
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