LLGL1/2 Antibody (Center S645/S649)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q6P1M3 |
Other Accession | Q3TJ91, Q8K4K5, Q80Y17, Q15334, Q8MKF0, NP_004515.2, NP_001015002.1, NP_001026973.1 |
Reactivity | Human |
Predicted | Bovine, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 113448 Da |
Antigen Region | 624-653 aa |
Gene ID | 3993 |
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Other Names | Lethal(2) giant larvae protein homolog 2, HGL, LLGL2 |
Target/Specificity | This LLGL1/2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 624-653 amino acids from the Central region of human LLGL1/2. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | LLGL1/2 Antibody (Center S645/S649) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | LLGL2 |
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Function | Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par- 6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity. |
Cellular Location | Cytoplasm. Note=Localized in the perinuclear structure and faintly at the cell- cell contacts sites in the interphase. Localized at the cell periphery during metaphase. Cortical localization in mitotic cells. Found in the lateral region of polarized epithelial cells |
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Provided below are standard protocols that you may find useful for product applications.
Background
The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms.
References
Lisovsky, M., et al. Hum. Pathol. 41(6):902-909(2010)
Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)
Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)
Yamada, Y., et al. Atherosclerosis 207(1):144-149(2009)
Lisovsky, M., et al. Mod. Pathol. 22(7):977-984(2009)
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