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SYNPO Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8N3V7 |
| Other Accession | NP_001103444.1, NP_001159681.1, NP_001159680.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 99463 Da |
| Antigen Region | 654-683 aa |
| Gene ID | 11346 |
|---|---|
| Other Names | Synaptopodin, SYNPO, KIAA1029 |
| Target/Specificity | This SYNPO antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 654-683 amino acids from the C-terminal region of human SYNPO. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SYNPO Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SYNPO |
|---|---|
| Synonyms | KIAA1029 |
| Function | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). |
| Cellular Location | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8CC35}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q8CC35}. Perikaryon {ECO:0000250|UniProtKB:Q8CC35}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q8CC35}. Postsynaptic density {ECO:0000250|UniProtKB:Q8CC35}. Synapse {ECO:0000250|UniProtKB:Q8CC35} Cytoplasm, cytosol. Note=Localized at the tight junction of cells. In brain, localized to the postsynaptic densities and in the perikarya. Associated with dendritic spines of a subset of synapses. {ECO:0000250|UniProtKB:Q8CC35} |
| Tissue Location | Expressed in cerebral cortex. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Synaptopodin is an actin-associated protein that may play a role in actin-based cell shape and motility. The name synaptopodin derives from the protein's associations with postsynaptic densities and dendritic spines and with renal podocytes (Mundel et al., 1997 [PubMed 9314539]).[supplied by OMIM].
References
Kim, E.Y., et al. Am. J. Physiol. Renal Physiol. 299 (3), F594-F604 (2010) :
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
Dai, S., et al. Nephrol. Dial. Transplant. 25(3):824-835(2010)
Duning, K., et al. J. Am. Soc. Nephrol. 19(10):1891-1903(2008)
Garovic, V.D., et al. Nephrol. Dial. Transplant. 22(4):1136-1143(2007)
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