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ETV6 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ETV6 Antibody (Center) AP14496c
    ETV6 Antibody (Center) (Cat. #AP14496c) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the ETV6 antibody detected the ETV6 protein (arrow).
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P41212
Other Accession Q0VC65, NP_001978.1
Reactivity Mouse
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 53000 Da
Antigen Region 173-202 aa
Additional Information
Gene ID 2120
Other Names Transcription factor ETV6, ETS translocation variant 6, ETS-related protein Tel1, Tel, ETV6, TEL, TEL1
Target/Specificity This ETV6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 173-202 amino acids from the Central region of human ETV6.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsETV6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ETV6
Synonyms TEL, TEL1
Function Transcriptional repressor; binds to the DNA sequence 5'- CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation.
Cellular Location Nucleus.
Tissue Location Ubiquitous.
Citations (0)
citation

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Background

This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.

References

Otsubo, K., et al. Cancer Genet. Cytogenet. 202(1):22-26(2010)
Roukens, M.G., et al. Nat. Cell Biol. 12(10):933-942(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Gascon, E., et al. J. Neurosci. 30(37):12414-12423(2010)
Liang, D.C., et al. Pediatr Blood Cancer 55(3):430-433(2010)

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$ 182.50
$ 70.00
Cat# AP14496c
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