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ETV6 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P41212 |
| Other Accession | Q0VC65, NP_001978.1 |
| Reactivity | Mouse |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 53000 Da |
| Antigen Region | 173-202 aa |
| Gene ID | 2120 |
|---|---|
| Other Names | Transcription factor ETV6, ETS translocation variant 6, ETS-related protein Tel1, Tel, ETV6, TEL, TEL1 |
| Target/Specificity | This ETV6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 173-202 amino acids from the Central region of human ETV6. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ETV6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ETV6 |
|---|---|
| Synonyms | TEL, TEL1 |
| Function | Transcriptional repressor; binds to the DNA sequence 5'- CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. |
| Cellular Location | Nucleus. |
| Tissue Location | Ubiquitous. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.
References
Otsubo, K., et al. Cancer Genet. Cytogenet. 202(1):22-26(2010)
Roukens, M.G., et al. Nat. Cell Biol. 12(10):933-942(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Gascon, E., et al. J. Neurosci. 30(37):12414-12423(2010)
Liang, D.C., et al. Pediatr Blood Cancer 55(3):430-433(2010)
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