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BCAS2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O75934 |
| Other Accession | Q9D287, Q5RKQ0, NP_005863.1 |
| Reactivity | Human |
| Predicted | Zebrafish, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 26131 Da |
| Antigen Region | 21-49 aa |
| Gene ID | 10286 |
|---|---|
| Other Names | Pre-mRNA-splicing factor SPF27, Breast carcinoma-amplified sequence 2, DNA amplified in mammary carcinoma 1 protein, Spliceosome-associated protein SPF 27, BCAS2, DAM1 |
| Target/Specificity | This BCAS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-49 amino acids from the N-terminal region of human BCAS2. |
| Dilution | WB~~1:500 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | BCAS2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BCAS2 |
|---|---|
| Synonyms | DAM1 {ECO:0000303|PubMed:10403562} |
| Function | Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:30705154). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). |
| Cellular Location | Nucleus. Nucleus, nucleolus |
| Tissue Location | Ubiquitously expressed. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
BCAS2 is involved in mRNA splicing (By similarity).
References
Kuo, P.C., et al. Cancer Res. 69(23):8877-8885(2009)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Qi, C., et al. Biochem. Biophys. Res. Commun. 328(2):393-398(2005)
Lee, S., et al. Cancer Lett. 188 (1-2), 121-126 (2002) :
Maass, N., et al. Cancer Lett. 185(2):219-223(2002)
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