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Mouse Map3k1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P53349 |
| Other Accession | Q13233 |
| Reactivity | Mouse |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 161289 Da |
| Antigen Region | 1194-1221 aa |
| Other Names | Mitogen-activated protein kinase kinase kinase 1, MAPK/ERK kinase kinase 1, MEK kinase 1, MEKK 1, Map3k1, Mekk, Mekk1 |
|---|---|
| Target/Specificity | This Mouse Map3k1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1194-1221 amino acids from the C-terminal region of mouse Map3k1. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Map3k1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Map3k1 |
|---|---|
| Synonyms | Mekk, Mekk1 |
| Function | Component of a protein kinase signal transduction cascade (PubMed:14500727). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:14500727). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:14500727). |
| Tissue Location | Highly expressed in the heart and spleen while a lower level expression is seen in the liver |
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Provided below are standard protocols that you may find useful for product applications.
Background
Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.
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